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NCJ Number: NCJ 224522   Add to Shopping cart   Find in a Library
Title: Forensic Toxicology Research and Development Evaluation of New and Novel Direct Sample Introduction, Time of Flight Mass Spectrometry (AccuTOF-DART) Instrument for Postmortem Toxicology Screening, Final Report
Author(s): Peter R. Stout ; Jeri D. Ropero-Miller
Corporate Author: RTI International
United States of America
Date Published: 08/2008
Page Count: 321
Sponsoring Agency: National Institute of Justice
US Department of Justice
Office of Justice Programs
United States of America
Grant Number: 2006-DN-BX-K014
Sale Source: National Institute of Justice/NCJRS
Box 6000
Rockville, MD 20849
United States of America

NCJRS Photocopy Services
Box 6000
Rockville, MD 20849-6000
United States of America
Document: PDF 
Type: Report (Study/Research)
Language: English
Country: United States of America
Annotation: The primary goal of this project was to evaluate a novel direct sample introduction time-of-flight (TOF) mass spectrometer (JEOL USA, Inc. AccuTOF-DART) for screening postmortem toxicology cases.
Abstract: The evalution found that, instrument is promising, because the very rapid sample analysis and potential broad sensitivity warrant efforts to improve sensitivity and the software. Early data indicate that this technology has advantages for postmortem toxicology analyses. These include minimal sample preparation, thus saving labor and improving sample integrity, and a broader ability to detect a range of compounds than is currently possible for most technologies. An evaluation of the instrument’s ability to detect 112 different drugs and metabolites of interest in postmortem toxicology found that most drugs could be detected, but that detection limits were too high to see likely therapeutic levels of many drugs. An examination of these compounds in urine again found that many drugs were detectable, but that detection limits were not sufficient for concentrations encountered. In blood and tissues, a similar pattern was observed. Interferences were encountered from isomers, which cannot be distinguished by exact mass, possibly unresolved compounds affecting mass determination, and other matrix components interfering with ionization. The project also evaluated an autosampler that greatly aided sample handling and contributed to the consistency of results. The JEOL, USA Inc. AccuTOF-DART is a well-constructed instrument that is easily maintained and is very robust; however, the software (Mass Center) is unstable and does not perform in a standard Windows fashion; it is problematic for forensic handling of data. Based on these findings, the instrument is currently useful for rapid screening of samples for which sensitivity is not a concern, such as drug chemistries. Further work to improve the instrument’s sensitivity and software could result in a useful instrument for biological samples and other applications. 25 figures, 15 tables, 14 references, and appended Methanolic Drug Standards and data on drugs in urine and in blood
Main Term(s): Drug detection
Index Term(s): Crime laboratory equipment ; Autopsy ; Poisons and poison analysis ; Computer software ; Mass spectroscopy ; Equipment evaluation ; Death investigations ; NIJ final report
   
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https://www.ncjrs.gov/App/Publications/abstract.aspx?ID=246488

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