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NCJRS Celebrates National Library Week April 12-18

National Library Week

Started in 1958, National Library Week is a nationwide observance celebrated by all types of libraries - including the NCJRS Virtual Library. NCJRS invites you to explore the breadth and scope of the NCJRS Virtual Library collection and services. With more than 220,000 collection documents and 60,000 online resources, including all known Office of Justice Programs works, it is one of the world’s largest criminal justice special collections.

We encourage your Feedback. Tell us how you use the NCJRS Virtual Library and Abstracts Database, how you access the collection, and any ways we can improve our services.

NCJRS Abstract

The document referenced below is part of the NCJRS Library collection.
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How to Obtain Documents
NCJ Number: NCJ 225533   Add to Shopping cart   Find in a Library
Title: Development of Microfluidic Devices for the Rapid Isolation and Detection of Drugs of Abuse
  Document URL: PDF 
Author(s): Bruce McCord ; Carla Turner ; Maximilien Blas ; Sandra Bishop ; Maggie Lerch ; Sacha Dehere ; Roberto Pannepucci
Date Published: 2008
Page Count: 76
  Annotation: This report describes the methodology and outcomes for a project designed to test the use of microchip-based devices for separating and analyzing drug compounds that have been implicated in drug-facilitated sexual assault, including phenethyl amines, GHB, and benzodiazepines.
Abstract: The project demonstrates the feasibility of using micro fluidic devices as a rapid screening tool for the detection of benzodiazepines used in beverages for committing drug-facilitated sexual assault (DFSA); however, for use in court, more definitive techniques are required. CEC/MS (capillary electrochromatography mass spectrometry) provides this capability in a micro fluidic format. Procedures developed for publication in the forensic literature include a micro fluidic procedure for the indirect detection of nitro benzodiazepines, a procedure for the trace detection of phenethyl amines using chip detection, an online preconcentration technique for the detection of a wide variety of drugs in urine using CE, a technique for the ultra trace detection of benzodiazepines by CEC/MS, and the development of chip-based designs for improved resolution of samples by fluorescent and electrochemical detection. Future work will continue to expand the application of chip-based screening and CEC/MS-TOF techniques to other drugs implicated in DFSA. This will minimize sample requirements and provide sensitive, disposable analytical systems for high throughput analysis. This report provides a detailed description of the methods used to achieve the detection of phenethyl amines on micro fluidic devices, the indirect detection of benzodiazepines, and the use of CEC/MS and monolithic CEC/MS-TOF for inline extraction. 9 tables, 18 figures and 74 references
Main Term(s): Drug analysis
Index Term(s): Chromatography ; Drug detection ; Criminal methods ; Sexual assault ; Mass spectroscopy ; Drug Related Crime ; Investigative techniques ; NIJ final report
Sponsoring Agency: National Institute of Justice (NIJ)
US Department of Justice
Office of Justice Programs
United States of America
Grant Number: 2004-WG-BX-K077
Sale Source: National Institute of Justice/NCJRS
Box 6000
Rockville, MD 20849
United States of America

NCJRS Photocopy Services
Box 6000
Rockville, MD 20849-6000
United States of America
Type: Report (Technical) ; Test/Measurement
Country: United States of America
Language: English
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